Prof. Dr. Georg Stoecklin

Prof. Dr. Georg Stoecklin

Mannheim Institute for Innate Immunoscience, Medical Faculty Mannheim, University of Heidelberg, Germany
Ludolf-Krehl-Str. 13 – 17
D-68167 Mannheim
Phone: +49 (621) 383-71444
E-mail: georg.stoecklin@medma.uni-heidelberg.de


Research Area

Biochemistry


Position and Status

Professor W3


Scholarships and awards

2002 - 2004 - Postdoctoral Fellowship, Swiss National Science Foundation
2001 - Paul Basset Prize, European Cancer Center Meeting, Strasbourg, France
2000 - Roche Research Foundation Award, Switzerland
1997 - 2000 - M.D./Ph.D. Fellowship, Swiss Academy of Medical Sciences
1996 - Medical Faculty Prize, University of Basel, Switzerland
1990 - Prix Ernest Leuba, University of Neuchâtel, Switzerland



University training and degree

1990 – 1997 Medical School, University of Basel, Switzerland
1989 – 1990 Medical School, University of Neuchâtel, Switzerland

 

Advanced academic qualifications

01/2013 - Habilitation (venia legendi) in Molecular Biology, Ruprecht Karls Universität Heidelberg, Germany
04/2000 - Ph.D. in Biology (Dr. phil. II) with Christoph Moroni, Institute for Medical Microbiology, University of Basel, Switzerland
01/1997 - M.D. (Dr. med.), University of Basel, Switzerland
11/1996 - Medical Licensing Exam (Staatsexamen) University of Basel, Switzerland

 

Postgraduate professional career

2016 - present - Professor for Biochemistry, Medical Faculty Mannheim at Heidelberg University
2006 - 2015 - Junior Group Leader, German Cancer Research Center (DKFZ) and Center for Molecular Biology at Heidelberg University (ZMBH)
2004 - 2006 - Instructor of Medicine, Harvard Medical School, Boston, USA
2002 - 2004 - Postdoctoral Fellow with Paul Anderson, Brigham and Women’s Hospital, Boston, MA, USA
2000 - 2001 - Postdoctoral Fellow with Christoph Moroni, Institute of Medical Microbiology, University of Basel, Switzerland

Coordinating functions and editorial work

2016 - present - Co-director, Centrum für Biomedizin und Medizintechnik Mannheim (CBTM)
2013 - Guest Editor, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
2012 - 2018 - Speaker of the Emerging Collaborative Topic 5 "Non-coding RNAs as versatile regulators of cellular processes" within the CellNetworks Excellence Cluster, University of Heidelberg
2011 - present - Academic Editor, PLoS One

Most important publications

  1. Stoecklin, G., Colombi, M., Raineri, I., Leuenberger, S., Mallaun, M., Schmidlin, M., Gross, B., Lu, M., Kitamura, T. & Moroni, C. Functional cloning of BRF1, a regulator of ARE- dependent mRNA turnover. The EMBO Journal 21, 4709-4718 (2002). https://doi.org/10.1093/emboj/cdf444
  2. Stoecklin, G., Stubbs, T., Kedersha, N., Wax, S., Rigby, W. F. C., Blackwell, T. K. & Anderson, P. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. The EMBO Journal 23, 1313-1324 (2004). https://doi.org/10.1038/sj.emboj.7600163
  3. Leppek, K., Schott, J., Reitter, S., Poetz, F., Hammond, M. C. & Stoecklin, G. Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs. Cell 153, 869-881 (2013). https://doi.org/10.1016/j.cell.2013.04.016
  4. Sharma, S., Poetz, F., Bruer, M., Ly-Hartig, Thi Bach N., Schott, J., Séraphin, B. & Stoecklin, G. Acetylation-Dependent Control of Global Poly(A) RNA Degradation by CBP/p300 and HDAC1/2. Molecular Cell 63, 927-938 (2016). https://doi.org/10.1016/j.molcel.2016.08.030
  5. Lafarga, V., Sung, H.-M., Haneke, K., Roessig, L., Pauleau, A.-L., Bruer, M., Rodriguez- Acebes, S., Lopez-Contreras, A. J., Gruss, O. J., Erhardt, S., Mendez, J., Fernandez- Capetillo, O. & Stoecklin, G. TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress. EMBO reports 20, e46224 (2019). https://doi.org/10.15252/embr.201846224
  6. Haneke, K., Schott, J., Lindner, D., Hollensen, A. K., Damgaard, C. K., Mongis, C., Knop, M., Palm, W., Ruggieri, A. & Stoecklin, G. CDK1 couples proliferation with protein synthesis. Journal of Cell Biology 219, e201906147 (2020). https://doi.org/10.1083/jcb.201906147
  7. Schott, J., Reitter, S., Lindner, D., Grosser, J., Bruer, M., Shenoy, A., Geiger, T., Mathes, A., Dobreva, G. & Stoecklin, G. Nascent Ribo-Seq measures ribosomal loading time and reveals kinetic impact on ribosome density. Nature Methods 18, 1068-1074 (2021). https://doi.org/10.1038/s41592-021-01250-z
  8. Poetz, F., Lebedeva, S., Schott, J., Lindner, D., Ohler, U. & Stoecklin, G. Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation. Genome Biology 23, 193 (2022). https://doi.org/10.1186/s13059-022-02760-5
  9. Poetz, F., Corbo, J., Levdansky, Y., Spiegelhalter, A., Lindner, D., Magg, V., Lebedeva, S., Schweiggert, J., Schott, J., Valkov, E. & Stoecklin, G. RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation. Nature Communications 12, 7175 (2021). https://doi.org/10.1038/s41467-021-27471-6
  10. Sung, H.-M., Schott, J., Boss, P., Lehmann, J. A., Hardt, M. R., Lindner, D., Messens, J., Bogeski, I., Ohler, U. & Stoecklin, G. Stress-induced nuclear speckle reorganization is linked to activation of immediate early gene splicing. Journal of Cell Biology 222, e202111151 (2023). https://doi.org/10.1083/jcb.202111151