Prof. Dr. Nils Blüthgen

Nils Bluethgen

Charite - Universitätsmedizin Berlin
Charitéplatz 1
10117 Berlin
Phone: +49 (30) 2093-9106 

Position and Status

Professor of Computational Modelling in Medicine (W2)

Scholarships and awards

2012 - EMBO Short-Term Fellowship, Institute Curie, Paris, France
2008 - MTZ-Award for Medical Systems Biology
2008-2009 - Honorary Lecturer, School of Translational Medicine, University of Manchester, UK

University training and degree

1998-2002 - Studies of Physics (Diplom, mit Auszeichnung) at Technische Universität Berlin
1996-1998 - Studies of Physics (Vordiplom) at Universität Heidelberg


Advanced academic qualifications

2006 - Promotion, Dr. rer. nat, Humboldt Universität zu Berlin (summa cum laude)


Postgraduate professional career

Since 2014 - Professor (tenure) for Computational Modelling in Medicine, Charité Universitätsmedizin Berlin und IRI Life Sciencens, Humboldt Universität Berlin
2009-2013 - Independent Junior Group Leader and Junior Professor (from 2011) in Medical Systems Biology, Charité Universitätsmedizin Berlin
2007-2008 - Research Fellow (tenure track) at Manchester Interdisciplinary Biocentre University Manchester, UK
2005-2007 - Postdoc at the Institute of Molecular Neuroscience, FU Berlin, Germany

Coordinating functions and editorial work

Since 2019 - Deputy Speaker, Steering committee for Genomics, Berlin Institute of Health
Since 2019 - Speaker DFG RTG 2424/1, CompCancer
Since 2015 - Deputy Speaker, Interdisciplinary Research Institute for the Life Sciences
Since 2015 - Speaker, Steering board for bioinformatics, Berlin Institute of Health

Most important publications

  1. Brandt, R.*, Sell, T.*, Luethen, M., Uhlitz, F., Klinger, B., Riemer, P., Giesecke, C., Schulze, S., El- Shimy, I. A., Kunkel, D., Fauler, B., Mielke, T., Mages, N., Herrmann, B. G., Sers, C., Blüthgen, N.* and Morkel, M.* (2019) Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium. Nature Communications, 10 (1): 2919

  2. Dorel, M., Klinger, B., Sieber, A., Prahallad, A., Gross, T., Bosdriesz, E., Wessels, L. and Blüthgen, N. (2018) Modelling Signalling Networks from Perturbation Data. Bioinformatics, 34: 4079-4086

  3. Uhlitz, F., Sieber, A., Wyler, E., Fritsche-Guenther, R., Meisig, J., Landthaler, M., Klinger, B. and Blüthgen, N. (2017) An immediate-late gene expression module decodes ERK signal duration. Molecular Systems Biology 13: 928

  4. Eduati, F., Doldàn-Martelli, V., Klinger, B., Cokelaer, T., Sieber, A., Kogera, F., Dorel, M., Garnett, M. J., Blüthgen, N. * and Saez-Rodriguez, J. * (2017) Drug resistance mechanisms in colorectal cancer dissected with cell type-specific dynamic logic models. Cancer Research, 77: 3364–75

  5. Schmiedel, J. M., Klemm, S., Zheng, Y., Sahay, A., Blüthgen, N.*, Marks, D.S.* and Oudenaarden, A.v.* (2015) MicroRNA control of protein expression noise. Science, 348: 128-132

  6. Bentele, K., Saffert, P., Rauscher, R., Ignatova, Z. and Blüthgen, N. (2013) Efficient translation initiation dictates codon usage at gene start. Molecular Systems Biology, 9: 675

  7. Klinger, B., Sieber, A., Fritsche-Guenther, R., Witzel, F., Berry, L., Schumacher, D., Yan, Y., Durek, P., Merchant, M., Schäfer, R., Sers, C. and Blüthgen, N. (2013) Network quantification of EGFR signaling unveils potential for targeted combination therapy. Molecular Systems Biology, 9: 673

  8. Stelniec, I., Legewie, S., Tchernitsa, O., Witzel, F., Klinger, B., Sers, C., Herzel, H., Blüthgen, N.* and Schäfer, R.* (2012) Reverse-engineering a hierarchical regulatory network downstream of oncogenic KRAS. Molecular Systems Biology, 8: 601

  9. Nora, E. P., Lajoie, B. R., Schulz, E. G., Giorgetti, L., Okamoto, I., Servant, N., Piolot, T., Berkum, N. L. v., Meisig, J., Sedat, J., Gribnau, J., Barillot, E., Blüthgen, N., Dekker, J. and Heard, E.. (2012) Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature, 485: 381-385

  10. Fritsche-Guenther, R., Witzel, F., Sieber, A., Herr, R., Schmidt, N., Braun, S., Brummer, T., Sers, C. and Blüthgen, N. (2011) Strong negative feedback from Erk to Raf confers robustness to MAPK signalling. Molecular Systems Biology, 7: 489

* joint corresponding/equal contribution