Prof. Dr. Thomas Höfer

Thomas Hoefer

Deutsches Krebsforschungszentrum
und Bioquant Zentrum, Universität Heidelberg
Im Neuenheimer Feld 280
69120 Heidelberg
Phone: +49 (6221) 54-51380

Position and Status

Head of DKFZ Division, Theoretical Systems Biology Professor of Theoretical Systems Biology (W3)

Scholarships and awards

2019/2020 - Visiting professorship, École Normale Supérieur, Paris
2018 - Offered professorship at Imperial College London and Head of the Integrative Biology section, MRC London Institute of Medical Science (not realized)
2011 - Reinhart Heinrich Lecture, International Study Group for Systems Biology
1994 - 1996 - Jowett Senior Scholar, Balliol College Oxford
1994 - Landahl Award, Society for Mathematical Biology
1993 - 1996 - PhD scholarship, Boehringer Ingelheim Fonds
1991 - 1993 - Studienstiftung des deutschen Volkes

University training and degree

09/1992 - 08/1993 - Diplom (MSc) dissertation, jointly with James D. Murray and Reinhart Heinrich
09/1988 - 07/1992 - Diplom (MSc) studies in Biophysics, Humboldt University Berlin


Advanced academic qualifications

1996 - PhD, with Philip Maini, mathematical sciences, Mathematical Institute, Center of Mathematical Biology, University of Oxford, UK


Postgraduate professional career

2013 - present - Professor (W3), Faculty of Biosciences, Heidelberg University
2011 - present - Head of Division, Theoretical Systems Biology, DKFZ
2007 - 2011 - Group leader (tenured), Modeling of Biological Systems, DKFZ
2002 - 2006 - Junior Professor (W1), Theoretical Biophysics, Humboldt University Berlin
2000 - 2002 - Group leader, Institute of Biology, Humboldt University Berlin
1997 - 2000 - Postdoctoral researcher, Institute of Biology, Humboldt University Berlin
1996 - 1997 - Guest scientist, Max Planck Institute of Complex Biological Systems, Dresden

Coordinating functions and editorial work

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2019 - present - Editorial board, Cell Systems
2015 - present - Coordinator, European (ERA CoSysMed) research consortium OPTIMIZE- NB – Optimizing first-line therapies of aggressive neuroblastoma by systems medicine strategies
2013 - present - Editorial board, European Journal of Immunology
2013 - present - Steering committee, Cluster of Excellence CellNetworks (EXC81)
2013 - 2017 - Coordinator, E:Bio Research consortium ImmunoQuant – Multi-scale Modelling of Innate Immune Responses to Viral Infection (funded by Federal Ministry for Education and Research)
2000 - 2006 - Steering committee, DFG Collaborative Research Centre, Theoretical Biology (SFB 618), Humboldt University Berlin

Most important publications

  1. Körber V, Yang J, Barah Tonn JC, Schackert G, Sabel M, Felsberg J, Zacher A, Kaulich K, Hübschmann D, Herold-Mende C, von Deimling A, Weller M, Radlwimmer B, Schlesner M, Reifenberger G*, Höfer T*, Lichter P* (2019) Evolutionary trajectories of IDH-WT glioblastomas reveal a common path of early tumorigenesis instigated years ahead of initial diagnosis. Cancer Cell 35, 692-704

  2. Li C, Cesbron F, Oehler M, Brunner M*, Höfer T* (2018) Frequency modulation of transcriptional bursting enables sensitive and rapid gene regulation. (*joint corresponding authors) Cell Systems 6, 409-423

  3. Ryl T, Kuchen EE, Bell E, Shao C, Floréz A, Moenke G, Gogolin S, Friedrich M, Lamprecht F, Westermann F, Höfer T (2017) Cell-cycle position of single MYC-driven cancer cells dictates their susceptibility to a chemotherapeutic drug. Cell Systems 5, 237-250

  4. Pei W, Feyerabend TB, Rössler J, Wang X, Postrach D, Busch K, Klapproth K, Rode I, Dietlein N, Quedenau C, Chen W, Sauer S, Wolf S, Höfer T*, Rodewald HR* (2017) Endogenous barcoding reveals hematopoietic stem cell fates realized in vivo. Nature 548, 456-460

  5. Busch K, Klapproth K, Barile M, Flossdorf M, Holland-Letz M, Schlenner SM, Reth M, Höfer T*, Rodewald HR* (2015) Fundamental properties of unperturbed hematopoiesis from stem cells in vivo. Nature 518, 542-546

  6. Buchholz VR#, Flossdorf M#, Hensel I, Kretschmer L, Gräf P, Schiemann M, Höfer T*, Busch DH* (2013) Disparate individual fates compose robust CD8+ T cell immunity. Science 340, 630-635

  7. Luijsterburg MS, von Bornstaedt G, Gourdin AM, Politi AZ, Moné MJ, Warmerdam DO, Goedhart J, Vermeulen W, van Driel R*, Höfer T* (2010) Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair. Journal of Cell Biology 189, 445-463

  8. Mariani L, Schulz E, Lexberg M, Helmstetter C, Radbruch A, Löhning M, Höfer T (2010) Short-term memory in gene induction reveals the regulatory principle behind stochastic interleukin-4 expression. Molecular Systems Biology 6:359

  9. Busse D, de la Rosa M, Hobiger K, Thurley K, Flossdorf M, Scheffold A, Höfer T (2010) Competing feedback loops shape IL-2 signaling between helper and regulatory T cells in cellular microenvironments. Proceedings of the National Academy of Sciences of the USA 107, 3058–3063

  10. Schulz E, Mariani L, Radbruch A, Höfer T (2009) Sequential polarization and imprinting of T-helper type 1 differentiation by interferon-γ and interleukin-12. Immunity 30, 678-688