Prof. Dr. Stephan Sigrist

StephanSigrist

Freie Universität Berlin
Institut für Biologie
Takustr. 6
14195 Berlin
Phone: +49 (30) 8385 6940
E-mail: stephan.sigrist@fu-berlin.de


Research Area

Biochemistry


Position and Status

Full Professor of Biochemistry (W3)


Scholarships and awards

2023 ERC Advanced Grant awarded

2014 - present -  Einstein Professorship of the Einstein Foundation Berlin, Germany
2005 - Best Habilitation Award awarded by the University Medical Center Göttingen, Georg-August-Universität Göttingen, Germany
2000 - EMBO Long-term Fellowship: Funding of Postdoc position by European Molecular Biology Organization Heidelberg, Germany
2000 - HFSP Long-term Fellowship: Funding of Postdoc position, Long-term Fellowship Human Frontier Science Program Organization Strasbourg, France



University training and degree

1988 - 1992 - Study of Biochemistry, Universität Tübingen, Diploma, Prof. Dr. Lehner
1986 - 1988 - Study of Chemistry, Technische Universität Berlin

 

Advanced academic education

2005 Habilitation in Biochemistry, Georg-August University Göttingen, Medical Faculty
1997 PhD in Biology, University of Tübingen, Prof. Dr. C. Lehner

 

Postgraduate professional career

2008 - present - Full professor of Biochemistry (W3), FU Berlin and Charité Universitätsmedizin Berlin
2006 - 2008 - Professor (W2), Experimental Biomedicine and Bio-Imaging, University of Würzburg
2000 - 2005 - Group leader, Independent Max-Planck-Research Group “Neuroplasticity”, European Neuroscience Institute (ENI), Göttingen
1997 - 2000 - Postdoctoral fellow, Laboratory of Christoph Schuster, Max-Planck-Institut Tübingen

Steering Committee member of SupraFAB imaging facility at FU Berlin

Elected Member of DFG study section "Neurobiology"

Spokesman SFB 958 Membrane Scaffolding

Directorial Board Member, Cluster of Excellence “NeuroCure”

Scientific Advisory Board University of Graz

Scientific Advisory Board Leibniz-Institute for Neurobiology, Magdeburg

Scientific Advisory Board Leibniz Institute for Aging, Jena

Most important publications

  1. Pooryasin, A., Maglione, M., Schubert, M., Matkovic-Rachid, T., Hasheminasab, S.-m., Pech, U., Fiala, A., Mielke, T. & Sigrist, S. J. Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila. Nature Communications 12, 1932 (2021). https://doi.org/10.1038/s41467-021-22180-6
  2. Petzoldt, A. G., Götz, T. W. B., Driller, J. H., Lützkendorf, J., Reddy-Alla, S., Matkovic-Rachid, T., Liu, S., Knoche, E., Mertel, S., Ugorets, V., Lehmann, M., Ramesh, N., Beuschel, C. B., Kuropka, B., Freund, C., Stelzl, U., Loll, B., Liu, F., Wahl, M. C. & Sigrist, S. J. RIM-binding protein couples synaptic vesicle recruitment to release sites. Journal of Cell Biology 219, e201902059 (2020). https://doi.org/10.1083/jcb.201902059
  3. Böhme, M. A., Beis, C., Reddy-Alla, S., Reynolds, E., Mampell, M. M., Grasskamp, A. T., Lützkendorf, J., Bergeron, D. D., Driller, J. H., Babikir, H., Göttfert, F., Robinson, I. M., O'Kane, C. J., Hell, S. W., Wahl, M. C., Stelzl, U., Loll, B., Walter, A. M. & Sigrist, S. J. Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling. Nature Neuroscience 19, 1311-1320 (2016). https://doi.org/10.1038/nn.4364
  4. Gupta, V. K., Scheunemann, L., Eisenberg, T., Mertel, S., Bhukel, A., Koemans, T. S., Kramer, J. M., Liu, K. S. Y., Schroeder, S., Stunnenberg, H. G., Sinner, F., Magnes, C., Pieber, T. R., Dipt, S., Fiala, A., Schenck, A., Schwaerzel, M., Madeo, F. & Sigrist, S. J. Restoring polyamines protects from age-induced memory impairment in an autophagy- dependent manner. Nature Neuroscience 16, 1453-1460 (2013). https://doi.org/10.1038/nn.3512
  5. Owald, D., Khorramshahi, O., Gupta, V. K., Banovic, D., Depner, H., Fouquet, W., Wichmann, C., Mertel, S., Eimer, S., Reynolds, E., Holt, M., Aberle, H. & Sigrist, S. J. Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly. Nature Neuroscience 15, 1219-1226 (2012). https://doi.org/10.1038/nn.3183
  6.  Liu, K. S. Y., Siebert, M., Mertel, S., Knoche, E., Wegener, S., Wichmann, C., Matkovic, T., Muhammad, K., Depner, H., Mettke, C., Bückers, J., Hell, S. W., Müller, M., Davis, G. W., Schmitz, D. & Sigrist, S. J. RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release. Science 334, 1565-1569 (2011). https://doi.org/10.1126/science.1212991
  7. Kittel, R. J., Wichmann, C., Rasse, T. M., Fouquet, W., Schmidt, M., Schmid, A., Wagh, D. A., Pawlu, C., Kellner, R. R., Willig, K. I., Hell, S. W., Buchner, E., Heckmann, M. & Sigrist, S. J. Bruchpilot Promotes Active Zone Assembly, Ca2+ Channel Clustering, and Vesicle Release. Science 312, 1051-1054 (2006). https://doi.org/10.1126/science.1126308
  8. Rasse, T. M., Fouquet, W., Schmid, A., Kittel, R. J., Mertel, S., Sigrist, C. B., Schmidt, M., Guzman, A., Merino, C., Qin, G., Quentin, C., Madeo, F. F., Heckmann, M. & Sigrist, S. J. Glutamate receptor dynamics organizing synapse formation in vivo. Nature Neuroscience 8, 898-905 (2005). https://doi.org/10.1038/nn1484
  9. Sigrist, S. J., Thiel, P. R., Reiff, D. F., Lachance, P. E. D., Lasko, P. & Schuster, C. M. Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. Nature 405, 1062-1065 (2000). https://doi.org/10.1038/35016598 
  10. Sigrist, S. J. & Lehner, C. F. Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles. Cell 90, 671-681 (1997). https://doi.org/10.1016/S0092-8674(00)80528-0