Prof. Dr. Dorothea Fiedler

Dorothea Fiedler

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
Robert-Rössle-Str. 10
13125 Berlin
Phone: +49 (030) 94793 151
E-mail: fiedler@fmp-berlin.de



Position and Status

Professor of Chemical Biology (W3-S), HU Berlin Managing Director, FMP


Scholarships and awards

2013 - NIH Director’s New Innovator Award
2013 - Rita Allen Scholar Award
2013 - Kimmel Scholar Award
2009 - NIH Pathway to Independence Award
2007 - Fasttrack Program, Robert Bosch Stiftung
2007 - Schering Stiftung Postdoctoral Fellowship
2005 - Young Investigator Award (ACS Inorganic Division)
2000 - Bayer AG Fellowship (for Diploma thesis abroad)
1998 - German National Merit Foundation (Studienstiftung des Deutschen Volkes)



University training and degree

09/2000 - 08/2001 - Diploma thesis with John Arnold, College of Chemistry, University of California at Berkley, CA. External supervision by Helmut Werner, Julius-Maximilians Universität Würzburg
10/1996 - 08/2001 - Studies of Chemistry at the Julius-Maximilians Universität Würzburg

 

Advanced academic qualifications

2005 - Ph.D. in Chemistry, University of Californa at Berkeley, CA, USA. Supervisors: K. N. Raymond and R. G. Bergman
2001 - Diplom in Chemistry, Julius-Maximilians Universität Würzburg. Supervisors: H. Werner and J. Arnold

 

Postgraduate professional career

7/2015 - present - Professor of Chemical Biology (W3-S), HU Berlin; and Head of Department Chemical Biology I, FMP, Berlin
8/2010 – 6/2015 - Assistant Professor of Chemistry, Princeton University, NJ, USA
1/2006 – 6/2010 - Postdoctoral Fellow with Kevan M. Shokat at University of California at San Francisco, USA

Coordinating functions and editorial work

2020 – 2022 Coordinator of DFG priority program SPP1710 “Dynamics of Thiol-Based Redox Switches in Cellular Physiology”

2019 - present - PI and board member of UniSysCat, Cluster of Excellence, Berlin
2017 - present - Managing Director, FMP, Berlin
2015 - 2016 - Deputy Director, FMP, Berlin
2015 - present - Editorial Advisory Board, ChemBioChem, Wiley
2015 - present - Editorial Advisory Board, ACS Chemical Biology, ACS

Most important publications

  1. Kurz, L., Schmieder, P., Veiga, N. & Fiedler, D. One Scaffold, Two Conformations: The Ring-Flip of the Messenger InsP8 Occurs under Cytosolic Conditions. Biomolecules 13, 645 (2023).https://doi.org/10.3390/biom13040645
  2. Nguyen Trung, M., Kieninger, S., Fandi, Z., Qiu, D., Liu, G., Mehendale, N. K., Saiardi, A., Jessen, H., Keller, B. & Fiedler, D. Stable Isotopomers of myo-Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network. ACS Central Science 8, 1683-1694 (2022). https://doi.org/10.1021/acscentsci.2c01032
  3. Hostachy, S., Utesch, T., Franke, K., Dornan, G. L., Furkert, D., Türkaydin, B., Haucke, V., Sun, H. & Fiedler, D. Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs. Chemical Science 12, 10696-10702 (2021). https://doi.org/10.1039/D1SC02975D
  4. Bui, T. P. N., Mannerås-Holm, L., Puschmann, R., Wu, H., Troise, A. D., Nijsse, B., Boeren, S., Bäckhed, F., Fiedler, D. & deVos, W. M. Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health. Nature Communications 12, 4798 (2021). https://doi.org/10.1038/s41467-021-25081-w
  5. Furkert, D., Hostachy, S., Nadler-Holly, M. & Fiedler, D. Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome. Cell Chemical Biology 27, 1097- 1108.e1094 (2020). https://doi.org/10.1016/j.chembiol.2020.07.017
  6. Puschmann, R., Harmel, R. K. & Fiedler, D. Scalable Chemoenzymatic Synthesis of Inositol Pyrophosphates. Biochemistry 58, 3927-3932 (2019). https://doi.org/10.1021/acs.biochem.9b00587
  7. Harmel, R. K., Puschmann, R., Nguyen Trung, M., Saiardi, A., Schmieder, P. & Fiedler, D. Harnessing 13C-labeled myo-inositol to interrogate inositol phosphate messengers by NMR. Chemical Science 10, 5267-5274 (2019). DOI: https://doi.org/10.1039/C9SC00151D
  8. Marmelstein, Alan M., Morgan, J. A. M., Penkert, M., Rogerson, D. T., Chin, J. W., Krause, E. & Fiedler, D. Pyrophosphorylation via selective phosphoprotein derivatization. Chemical Science 9, 5929-5936 (2018). https://doi.org/10.1039/C8SC01233D
  9. Wu, M., Chong, L. S., Perlman, D. H., Resnick, A. C. & Fiedler, D. Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms. Proceedings of the National Academy of Sciences 113, E6757-E6765 (2016). https://doi.org/10.1073/pnas.1606853113
  10. Conway, J. H. & Fiedler, D. An Affinity Reagent for the Recognition of Pyrophosphorylated Peptides. Angewandte Chemie International Edition 54, 3941-3945 (2015). https://doi.org/10.1002/ange.201411232