Prof. Dr. Dorothea Fiedler

Dorothea Fiedler

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
Robert-Rössle-Str. 10
13125 Berlin
Phone: +49 (030) 94793 151

Position and Status

Professor of Chemical Biology (W3-S), HU Berlin Managing Director, FMP

Scholarships and awards

2013 - NIH Director’s New Innovator Award
2013 - Rita Allen Scholar Award
2013 - Kimmel Scholar Award
2009 - NIH Pathway to Independence Award
2007 - Fasttrack Program, Robert Bosch Stiftung
2007 - Schering Stiftung Postdoctoral Fellowship
2005 - Young Investigator Award (ACS Inorganic Division)
2000 - Bayer AG Fellowship (for Diploma thesis abroad)
1998 - German National Merit Foundation (Studienstiftung des Deutschen Volkes)

University training and degree

09/2000 - 08/2001 - Diploma thesis with John Arnold, College of Chemistry, University of California at Berkley, CA. External supervision by Helmut Werner, Julius-Maximilians Universität Würzburg
10/1996 - 08/2001 - Studies of Chemistry at the Julius-Maximilians Universität Würzburg


Advanced academic qualifications

2005 - Ph.D. in Chemistry, University of Californa at Berkeley, CA, USA. Supervisors: K. N. Raymond and R. G. Bergman
2001 - Diplom in Chemistry, Julius-Maximilians Universität Würzburg. Supervisors: H. Werner and J. Arnold


Postgraduate professional career

7/2015 - present - Professor of Chemical Biology (W3-S), HU Berlin; and Head of Department Chemical Biology I, FMP, Berlin
8/2010 – 6/2015 - Assistant Professor of Chemistry, Princeton University, NJ, USA
1/2006 – 6/2010 - Postdoctoral Fellow with Kevan M. Shokat at University of California at San Francisco, USA

Coordinating functions and editorial work

2019 - current - PI and board member of UniSysCat, Cluster of Excellence, Berlin
2017 - current - Managing Director, FMP, Berlin
2015 - 2016 - Deputy Director, FMP, Berlin
2015 - current - Editorial Advisory Board, ChemBioChem, Wiley
2015 - current - Editorial Advisory Board, ACS Chemical Biology, ACS

Most important publications

  1. R. Puschmann, R. K. Harmel, D. Fiedler. (2019) Scalable chemoenzymatic synthesis of inositol pyrophosphates. Biochemistry, 58, 3927-3932

  2. R. K. Harmel, R. Puschmann, M. Nguyen Trung, A. Saiardi, P. Schmieder, D. Fiedler. (2019) Harnessing 13C-labeled myo-inositol to interrogate inositol phosphate messengers by NMR. Chem. Sci., 10, 5267- 5274

  3. M. Marmelstein, J. A. M. Morgan, M. Penkert, D. T. Rogerson, J. W. Chin, E. Krause, D. Fiedler. (2018) Pyrophosphorylation via selective phosphoprotein derivatization Chem. Sci., 9, 5929-5936

  4. M. Wu, L. S. Chong, D. H. Perlman, A. C. Resnick, D. Fiedler. (2016) The inositol polyphosphates intersect with protein signaling and metabolic networks via two distinct mechanisms. Proc. Nat. Acad. Sci. USA, 113, E6757-E6765

  5. F. J. Williams, D. Fiedler. (2016) A fluorescent sensor and gel stain for detection of pyrophosphorylated proteins. ACS Chem. Biol. 2016, 10, 1958-1963

  6. J. H. Conway, D. Fiedler.(2015) An affinity reagent for recognition of pyrophosphorylated peptides. Angew. Chem. Int. Ed., 54, 3941-3945

  7. M. Wu, L. S. Chong, S. Capolicchio, H. J. Jessen, A. C. Resnick, D. Fiedler. (2014) Elucidating diphosphoinositol polyphosphate function with non-hydrolyzable analogues. Angew. Chem. Int. Ed., 53, 7192-7197

  8. M. Marmelstein, L. M. Yates, J. H. Conway, D. Fiedler. (2014) Chemical pyrophosphorylation of functionally diverse peptides. J. Am. Chem. Soc., 136, 108-111

  9. M. Wu, B. E. Dul, A. J. Trevisan, D. Fiedler (2013) Synthesis and characterization of non-hydrolyzable diphosphoinositol polyphosphate messengers. Chem. Sci., 4, 405-410

  10. D. Fiedler, H. Braberg, M. Mehta, G. Chechik, G. Cagney, P. Mukherjee, A. C. Silva, M. Shales, S. R. Collins S. van Wageningen, P. Kemmeren, F. C. P. Holstege, J. S. Weissman, M. Christopher-Keogh, D. Koller, K. M. Shokat, N. J. Krogan (2009) Functional organization of the S. cerevisiae phosphorylation network. Cell, 136, 952-963