Prof. Dr. Ursula Klingmüller

Ursula Klingmüller

Deutsches Krebsforschungszentrum (DKFZ)
Im Neuenheimer Feld 280
69120 Heidelberg
Phone: +49 (6221) 42-4481
E-mail: U.klingmueller@dkfz.de


Research Area

Molecular biology and genetics


Position and Status

Head of Division Systems Biology of Signal Transduction (B200), DKFZ / Professor (W3) Ruprecht-Karls-Universität Heidelberg


Scholarships and awards

2022 -  Lecture at the German-Italian Center for European Excellence funded by the DFG on “Personalised Services for the Elders“ at the Villa Vigoni, Como, Italy

2022 - Opening lecture at the “International Conference on Systems Biology” (ICSB 2022), Berlin, Germany, which is the largest conference in the field

2020 - Member of the German Ethics Council

Since 2016 - Election as Member of the German Ethics Council
2013 - 2014 - President of "Hinterzartener Kreis der DFG für Krebsforschung"
2012 - Elected Member of the DFG "Hinterzartener Kreis"
2004 - R. Eils, U. Klingmüller, O. Wiestler, E. Wanker,. A.-P. Zeng, R. Balling. ‘Systems Biology of Complex Diseases’ Ideenwettbewerb Helmholtz Association
1997 - FEBS Anniversary Prize
1986 - DAAD-Fellowship for a lab course at the University College, London
1993 - 1994 - DFG-Research Fellowship



University training and degree

1988 - Diploma in molecular biology, cell biology and virology, University of Heidelberg; Diploma thesis, Group of Prof. Dr. Heinz Schaller, Center for Molecular Biology Heidelberg (ZMBH) (with distinction, October 1988)
1985 - Bachelor of Science, University of Bayreuth (with distinction, November 1985)

 

Advanced academic qualifications

2004 - Venia Legendi in Cell Biology, Heidelberg University, Germany
2000 - Habilitation and Venia Legendi in Molecular Biology and Genetics, University of Freiburg
1992 - Graduate studies at Heidelberg University, Doctoral Thesis, Group of Prof. Dr. Heinz Schaller, Center for Molecular Biology Heidelberg, Germany (ZMBH), (summa cum laude, May 1992)

 

Postgraduate professional career

Since 2011 - W3 Professor, Heidelberg University, Germany
Since 2007 - Head of the division ‘Systems Biology of Signal Transduction’, German Cancer Research Center (DKFZ), Heidelberg, Germany
2003 - 2007 - Group leader of the Boveri-group ‘Systems Biology of Signal Transduction’, German Cancer Research Center (DKFZ), Heidelberg, Germany
1996 - 2003 - Group leader of an independent junior group,(Hans-Spemann-Laboratories) Max-Planck-Institute for Immunbiology, Freiburg, Germany
1992 - 1996 - Postdoctoral fellow, Harvard Medical School (Group of Prof. Dr. Lewis
C. Cantley) and Whitehead Institute for Biomedical Research (Group of Prof. Dr. Harvey F. Lodish)

Coordinating functions and editorial work

2022 - Co-Spokesperson for the Research Area B at the DKFZ

2022 -  2021 - Chair of the Scientific Organization Committee of the International Conference “Systems Biology of Mammalian Cells“ (SBMC) in Heidelberg, Germany

2018  Co-Chair of the Organisation Committee of the EMBO Workshop supported by the DFG in Split, Croatia

Since 2015 - Associate Editor for Nature Systems Biology and Applications
Since 2014 - Chair of the Executive Women's Initiative at DKFZ
Since 2010 - Member in selection committees of the DKFZ
Since 2007 - Coordination (together with Prof. Ursula Kummer) of Major Systems Biology in the Master Program Molecular Biosciences at Heidelberg University
2007 - 2015 - Board of Trustees German Cancer Research Center (DKFZ)

Most important publications

  1. Chakraborty, S., Andrieux, G., Kastl, P., Adlung, L., Altamura, S., Boehm, M. E., Schwarzmüller, L. E., Abdullah, Y., Wagner, M.-C., Helm, B., Gröne, H.-J., Lehmann, W. D., Boerries, M., Busch, H., Muckenthaler, M. U., Schilling, M. & Klingmüller, U. Erythropoietin- driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo. Cell Reports 40, 111360 (2022). https://doi.org/10.1016/j.celrep.2022.111360
  2. Adlung, L., Kar, S., Wagner, M.-C., She, B., Chakraborty, S., Bao, J., Lattermann, S., Boerries, M., Busch, H., Wuchter, P., Ho, A. D., Timmer, J., Schilling, M., Höfer, T. & Klingmüller, U. Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation. Molecular Systems Biology 13, 904 (2017). https://doi.org/10.15252/msb.20167258
  3. Adlung, L., Stapor, P., Tönsing, C., Schmiester, L., Schwarzmüller, L. E., Postawa, L., Wang, D., Timmer, J., Klingmüller, U., Hasenauer, J. & Schilling, M. Cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes defines survival threshold in erythroid progenitor cells. Cell Reports 36, 109507 (2021). https://doi.org/10.1016/j.celrep.2021.109507
  4. Kok, F., Rosenblatt, M., Teusel, M., Nizharadze, T., Gonçalves Magalhães, V., Dächert, C., Maiwald, T., Vlasov, A., Wäsch, M., Tyufekchieva, S., Hoffmann, K., Damm, G., Seehofer, D., Boettler, T., Binder, M., Timmer, J., Schilling, M. & Klingmüller, U. Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction. Molecular Systems Biology 16, e8955 (2020). https://doi.org/10.15252/msb.20198955
  5. Duerr, J., Leitz, D. H. W., Szczygiel, M., Dvornikov, D., Fraumann, S. G., Kreutz, C., Zadora, P. K., Seyhan Agircan, A., Konietzke, P., Engelmann, T. A., Hegermann, J., Mulugeta, S., Kawabe, H., Knudsen, L., Ochs, M., Rotin, D., Muley, T., Kreuter, M., Herth, F. J. F., Wielpütz, M. O., Beers, M. F., Klingmüller, U. & Mall, M. A. Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice. Nature Communications 11, 2012 (2020). https://doi.org/10.1038/s41467-020-15743-6
  6. Lucarelli, P., Schilling, M., Kreutz, C., Vlasov, A., Boehm, M. E., Iwamoto, N., Steiert, B., Lattermann, S., Wäsch, M., Stepath, M., Matter, M. S., Heikenwälder, M., Hoffmann, K., Deharde, D., Damm, G., Seehofer, D., Muciek, M., Gretz, N., Lehmann, W. D., Timmer, J. & Klingmüller, U. Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression. Cell Systems 6, 75-89.e11 (2018). https://doi.org/10.1016/j.cels.2017.11.010
  7. Oppelt, A., Kaschek, D., Huppelschoten, S., Sison-Young, R., Zhang, F., Buck-Wiese, M., Herrmann, F., Malkusch, S., Krüger, C. L., Meub, M., Merkt, B., Zimmermann, L., Schofield, A., Jones, R. P., Malik, H., Schilling, M., Heilemann, M., van de Water, B., Goldring, C. E., Park, B. K., Timmer, J. & Klingmüller, U. Model-based identification of TNFα-induced IKKβ- mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds. npj Systems Biology and Applications 4, 23 (2018). https://doi.org/10.1038/s41540-018-0058-z
  8. Marwitz, S., Depner, S., Dvornikov, D., Merkle, R., Szczygieł, M., Müller-Decker, K., Lucarelli, P., Wäsch, M., Mairbäurl, H., Rabe, K. F., Kugler, C., Vollmer, E., Reck, M., Scheufele, S., Kröger, M., Ammerpohl, O., Siebert, R., Goldmann, T. & Klingmüller, U. Downregulation of the TGFβ Pseudoreceptor BAMBI in Non–Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion. Cancer Research 76, 3785-3801 (2016). DOI: 10.1158/0008-5472.CAN-15-1326
  9. Raia, V., Schilling, M., Böhm, M., Hahn, B., Kowarsch, A., Raue, A., Sticht, C., Bohl, S., Saile, M., Möller, P., Gretz, N., Timmer, J., Theis, F., Lehmann, W.-D., Lichter, P. & Klingmüller, U. Dynamic Mathematical Modeling of IL13-Induced Signaling in Hodgkin and Primary Mediastinal B-Cell Lymphoma Allows Prediction of Therapeutic Targets. Cancer Research 71, 693-704 (2011). DOI: 10.1158/0008-5472.CAN-10-2987
  10. Becker, V., Schilling, M., Bachmann, J., Baumann, U., Raue, A., Maiwald, T., Timmer, J. & Klingmüller, U. Covering a Broad Dynamic Range: Information Processing at the Erythropoietin Receptor. Science 328, 1404-1408 (2010). DOI: 10.1126/science.1184913

Patents

  1. Klingmüller, U., and Michnick, S., (1995), Assays for agents which alter erythropoietin activity. Pending US patent application 08/914,706.

  2. Swameye, I., Müller, T., Timmer, J., and Klingmüller, U., (2001), Methods,System and Use of the Method and the System for Identifying Targets for Efficient Medical Intervention and /or for Predicting the Effect of Therapeutic Agents and/or for Dynamically Modeling Complex Cell Signaling Networks. Patent pending. Pending US patent application 10/475,930.

  3. Schilling, M., Maiwald, T., Bohl, S., Kreutz, C., Timmer, J., and Klingmüller, U., (2005), Method for processing and error reduction for standardized quantitative data in biological networks, PCT/EP2006/069274.

  4. Schilling M., Rodriguez-Gonzalez, A., Timmer, J., Raue, A., Schelker, M., Klingmüller, U., Jarsch, M. (2014) Methods for the Prediction of a Perzonalized ESA-Dose in the Treatment of Anemia. EP14173054.9

  5. Rodriguez-Gonzalez, A., Schilling, M., Klingmüller, U., Timmer, J., and Steiert, B. (2017) Prediction- method of mortality due to treatment with erythropoiesis stimulating agents. EP17153796.2