Prof. Dr. Achim Kramer
Charité - Universitätsmedizin Berlin
Institut für Medizinische Immunologie
Arbeitsbereich Chronobiologie
Charitéplatz 1
10117 Berlin
Phone: +49 (30) 450-524263
E-mail: achim.kramer@charite.de
Research Area
Chronobiology
Position and Status
Professor of Chronobiology (W2)
Scholarships and awards
2010- present - Teaching Awards of the Charité Master-Program „Medical Neurosciences“
2007 - Call to a Full Professorship (W3) in Molecular Biology at the University Duisburg-Essen (declined)
2002 - Heinz-Maier-Leibnitz Award from the German Research Foundation (DFG)
2001 - Brooks Fellow at Harvard Medical School
1999 - 2001 - Postdoctoral fellowship from the German Research Foundation (DFG)
1998 - Young Researcher’s Award, Charité - Universitätsmedizin Berlin
1994 - 1996 - Graduation Fellowship of the "Fonds der Chemischen Industrie"
University training and degree
1993 - Diploma thesis with Jens Schneider-Mergener at Charité-Universitätsmedizin Berlin
1990 - 1994 - Study of Music (piano) at Hochschule der Künste, Berlin
1988 - 1993 - Study of Biochemistry at Freie Universität, Berlin
Advanced academic qualifikations
1996 - Ph.D. in Biochemistry, Institute of Medical Immunology, Humboldt Universität zu Berlin; Mentor: Jens Schneider-Mergener (summa cum laude)
1994 - Degree as Piano Teacher, Hochschule der Künste, Berlin
Postgraduate professional career
2011 - present - Chair of the independent Research Unit “Chronobiology” at Charité Universitätsmedizin Berlin
2007 - present - Professor for Chronobiology at Charité-Universitätsmedizin Berlin (W2, tenured)
2002 - 2007 - Assistant Professor (Juniorprofessor) for Chronobiology at Charité - Universitätsmedizin Berlin
2002 - 2007 - Junior Research Emmy-Noether Group Leader (German Research Fondation, DFG) at Charité Universitätsmedizin Berlin
1999 - 2001 - Postdoc at the Department of Neurobiology, Harvard Medical School, Boston, USA (Charles Weitz)
1998 - Postdoc at the Istituto Di Ricerche Di Biologia Moleculare (IRBM) in Rom, Italy (Riccardo Cortese)
1996 - 1999 - Postdoc at the Institute of Medical Immunology, Charité-Universitätsmedizin Berlin
Coordinating functions and editorial work
2024 - Program Chair Bienniel Meeding Society for Research on Biological Rhythms (SRBR)
2016 - present - Member of steering committee of TRR186
2015 - Chair of Gordon Research Conference “Chronobiology”
2014 - Member of “Executive Committee” der “Society for Research on Biological Rhythms”
2013 - Associate Editor of PLoS Genetics
2013 - Editorial Board Member of Journal of Biological Rhythms
2013 - Editor of “Circadian Clocks”, Handbook of Experimental Pharmacology (Springer)
2013 - Vice-Chair of Gordon Research Conference “Chronobiology”
2012 - Member of “Executive Board” of the „European Biological Rhythms Society“
Most important publications
- Schmal, C., Maier, B., Ashwal-Fluss, R., Bartok, O., Finger, A.-M., Bange, T., Koutsouli, S., Robles, M. S., Kadener, S., Herzel, H. & Kramer, A. Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock. PLOS Biology 21, e3002164 (2023). https://doi.org/10.1371/journal.pbio.3002164
- Klemz, S., Wallach, T., Korge, S., Rosing, M., Klemz, R., Maier, B., Fiorenza, N. C., Kaymak, I., Fritzsche, A. K., Herzog, E. D., Stanewsky, R. & Kramer, A. Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity. Genes & Development 35, 1161-1174 (2021). DOI:10.1101/gad.348622.121
- Gabriel, C. H., del Olmo, M., Zehtabian, A., Jäger, M., Reischl, S., van Dijk, H., Ulbricht, C., Rakhymzhan, A., Korte, T., Koller, B., Grudziecki, A., Maier, B., Herrmann, A., Niesner, R., Zemojtel, T., Ewers, H., Granada, A. E., Herzel, H. & Kramer, A. Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells. Nature Communications 12, 3796 (2021). https://doi.org/10.1038/s41467-021-24086-9
- Wittenbrink, N., Ananthasubramaniam, B., Münch, M., Koller, B., Maier, B., Weschke, C., Bes, F., de Zeeuw, J., Nowozin, C., Wahnschaffe, A., Wisniewski, S., Zaleska, M., Bartok, O., Ashwal-Fluss, R., Lammert, H., Herzel, H., Hummel, M., Kadener, S., Kunz, D. & Kramer, A. High-accuracy determination of internal circadian time from a single blood sample. The Journal of Clinical Investigation 128, 3826-3839 (2018). DOI: 10.1172/JCI120874
- Finger, A.-M., Jäschke, S., del Olmo, M., Hurwitz, R., Granada, A. E., Herzel, H. & Kramer, A. Intercellular coupling between peripheral circadian oscillators by TGF-β signaling. Science Advances 7, eabg5174 (2021). DOI: 10.1126/sciadv.abg517
- Klemz, R., Reischl, S., Wallach, T., Witte, N., Jürchott, K., Klemz, S., Lang, V., Lorenzen, S., Knauer, M., Heidenreich, S., Xu, M., Ripperger, J. A., Schupp, M., Stanewsky, R. & Kramer, A. Reciprocal regulation of carbon monoxide metabolism and the circadian clock. Nature Structural & Molecular Biology 24, 15-22 (2017). https://doi.org/10.1038/nsmb.3331
- Schmalen, I., Reischl, S., Wallach, T., Klemz, R., Grudziecki, A., Prabu, J. R., Benda, C., Kramer, A. & Wolf, E. Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation. Cell 157, 1203-1215 (2014). https://doi.org/10.1016/j.cell.2014.03.057
- Vanselow, K., Vanselow, J. T., Westermark, P. O., Reischl, S., Maier, B., Korte, T., Herrmann, A., Herzel, H., Schlosser, A. & Kramer, A. Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes & Development 20, 000 (2006). doi: 10.1101/gad.397006
- Kramer, A., Yang, F.-C., Snodgrass, P., Li, X., Scammell, T. E., Davis, F. C. & Weitz, C. J. Regulation of Daily Locomotor Activity and Sleep by Hypothalamic EGF Receptor Signaling. Science 294, 2511-2515 (2001). DOI: 10.1126/science.1067716
- Kramer, A., Keitel, T., Winkler, K., Stöcklein, W., Höhne, W. & Schneider-Mergener, J. Molecular Basis for the Binding Promiscuity of an Anti-p24 (HIV-1) Monoclonal Antibody. Cell 91, 799-809 (1997). https://doi.org/10.1016/S0092-8674(00)80468-7