Prof. Dr. Achim Kramer

Prof. Dr. Achim Kramer

Charité - Universitätsmedizin Berlin
Institut für Medizinische Immunologie
Arbeitsbereich Chronobiologie
Charitéplatz 1
10117 Berlin
Phone: +49 (30) 450-524263
E-mail: achim.kramer@charite.de



Position and Status

Professor of Chronobiology (W2)


Scholarships and awards

2010, 2011, 2013, 2015 - Teaching Awards of the Charité Master-Program „Medical Neurosciences“
2007 - Call to a Full Professorship (W3) in Molecular Biology at the University Duisburg-Essen (declined)
2002 - Heinz-Maier-Leibnitz Award from the German Research Foundation (DFG)
2001 - Brooks Fellow at Harvard Medical School
1999 - 2001 - Postdoctoral fellowship from the German Research Foundation (DFG)
1998 - Young Researcher’s Award, Charité - Universitätsmedizin Berlin
1994 - 1996 - Graduation Fellowship of the "Fonds der Chemischen Industrie"



University training and degree

1993 - Diploma thesis with Jens Schneider-Mergener at Charité-Universitätsmedizin Berlin
1990 - 1994 - Study of Music (piano) at Hochschule der Künste, Berlin
1988 - 1993 - Study of Biochemistry at Freie Universität, Berlin

 

Advanced academic qualifikations

1996 - Ph.D. in Biochemistry, Institute of Medical Immunology, Humboldt Universität zu Berlin; Mentor: Jens Schneider-Mergener (summa cum laude)
1994 - Degree as Piano Teacher, Hochschule der Künste, Berlin

 

Postgraduate professional career

2011 - present - Chair of the independent Research Unit “Chronobiology” at Charité Universitätsmedizin Berlin
2007 - present - Professor for Chronobiology at Charité-Universitätsmedizin Berlin (W2, tenured)
2002 - 2007 - Assistant Professor (Juniorprofessor) for Chronobiology at Charité - Universitätsmedizin Berlin
2002 - 2007 - Junior Research Emmy-Noether Group Leader (German Research Fondation, DFG) at Charité Universitätsmedizin Berlin
1999 - 2001 - Postdoc at the Department of Neurobiology, Harvard Medical School, Boston, USA (Charles Weitz)
1998 - Postdoc at the Istituto Di Ricerche Di Biologia Moleculare (IRBM) in Rom, Italy (Riccardo Cortese)
1996 - 1999 - Postdoc at the Institute of Medical Immunology, Charité-Universitätsmedizin Berlin

Coordinating functions and editorial work

2015 - Chair of Gordon Research Conference “Chronobiology”
2014 - Member of “Executive Committee” der “Society for Research on Biological Rhythms”
2013 - Associate Editor of PLoS Genetics
2013 - Editorial Board Member of Journal of Biological Rhythms
2013 - Editor of “Circadian Clocks”, Handbook of Experimental Pharmacology (Springer)
2013 - Vice-Chair of Gordon Research Conference “Chronobiology”
2012 - Member of “Executive Board” of the „European Biological Rhythms Society“

Most important publications

  1. Wittenbrink N, Ananthasubramaniam B, Münch M, Koller B, Maier B, Weschke C, Bes F, de Zeeuw J, Nowozin C, Wahnschaffe A, Wisniewski S, Zaleska M, Bartok O, Ashwal-Fluss R, Lammert H, Herzel H, Hummel M, Kadener S, Kunz D, Kramer A (2018) High-accuracy determination of internal circadian time from a single blood sample. J Clin Invest. 128:3826-3839

  2. Klemz R, Reischl S, Wallach T, Witte N, Jürchott K, Klemz S, Lang V, Lorenzen S, Knauer M, Heidenreich S, Xu M, Ripperger JA, Schupp M, Stanewsky R, Kramer A (2017) Reciprocal regulation of carbon monoxide metabolism and the circadian clock. Nat Struct Mol Biol. 24:15-22

  3. Schmalen I, Reischl S, Wallach T, Klemz R, Grudziecki A, Prabu JR, Benda C, Kramer A*, Wolf E* (2014) Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation. Cell 157:1203-1215 (*=corresponding authors)

  4. Czarna A, Berndt A, Singh HR, Grudziecki A, Ladurner AG, Timinszky G, Kramer A, Wolf E (2013) Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function. Cell 153:1394-405

  5. Spörl F, Korge S, Jürchott K, Wunderskirchner M, Schellenberg K, Heins S, Specht A, Stoll C, Klemz R, Maier B, Wenck H, Schrader A, Kunz D, Blatt T, Kramer A (2012) Krüppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes. Proc Natl Acad Sci USA. 109:10903-10908

  6. Maier B, Wendt S, Vanselow JT, Wallach T, Reischl S, Oehmke S, Schlosser A, Kramer A (2009) A large- scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock. Genes Dev. 23:708-718

  7. Keller M, Mazuch J, Abraham U, Eom GD, Herzog ED, Volk HD, Kramer A*, Maier B (2009) A circadian clock in macrophages controls inflammatory immune responses. Proc Natl Acad Sci USA. 106:21407- 12 (*=corresponding author)

  8. Vanselow K, Vanselow JT, Westermark PO, Reischl S, Maier B, Korte T, Herrmann A, Herzel H, Schlosser A, and Kramer A. (2006) Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes Dev. 20:2660-72

  9. Kramer A, Yang F-C, Snodgrass P, Li X-D, Scammel TE, Davis F, Weitz CJ (2001) Regulation of daily locomotor activity, sleep by hypothalamic EGF receptor signalling. Science 294:2511-2515

  10. Kramer A, Keitel T, Höhne W, Schneider-Mergener J (1997) Molecular basis of the binding promiscuity of an anti-p24 (HIV-1) monoclonal antibody. Cell 91, 799-809