Prof. Dr. Markus Wahl

Prof. Dr. Markus Wahl

Freie Universität Berlin
Institut für Chemie und Biochemie
Takustr. 6
14195 Berlin
Phone: +49 (0) 30 838-53456

Position and Status

Professor of Structural Biochemistry (W3)

Scholarships and awards

2014 - Elected Member of the European Molecular Biology Organization (EMBO)
2011 - Award for Excellent Teaching, Institute of Chemistry and Biochemistry, Freie Universität Berlin
1999, 2001 - Postdoctoral Fellowship, Peter und Traudl Engelhorn-Stiftung
1999 - Sidhu Award, Pittsburgh Diffraction Society
1997 - Postdoctoral Fellowship, Deutsche Forschungsgemeinschaft
1996 - Presidential Fellowship, The Ohio State University
1995 - Chung Soo Yoo Award, Pittsburgh Diffraction Society
1995 - Graduate Research Award, Department of Biochemistry, The Ohio State University
1993 - Wilbur Wright Canaga Fellowship, The Ohio State University
1991 - University Fellowship, The Ohio State University
1990 - Fulbright Fellowship, Fulbright Association

University training and degree

1992 - 1993 - Master thesis with Alan G. Marshall, The Ohio State University
1991 - 1993 - Study of Biochemistry, The Ohio State University
1990 - 1991 - Fulbright Fellow in Biochemistry, University of Rochester
1987 - 1990 - Study of Biochemistry, Leibniz Universität Hannover (Vordiplom 1989)


Advanced academic qualifications

2002 - Habilitation (venia legendi) in Biochemistry
Technische Universität München; Mentor: Robert Huber
1996 - PhD in Biochemistry, The Ohio State University; Mentor: Muttaiya Sundaralingam


Postgraduate professional career

2019 - present - Faculty Member, International Max-Planck-Research School “Biology and Computation”, Max-Planck-Institute for Molecular Genetics, Berlin, Germany
2017 - present - Head of the Joint Research Group “Macromolecular Crystallography”, Helmholtz-Zentrum Berlin/Freie Universität Berlin, Germany
2009 - present - Professor (W3) of Structural Biochemistry, Freie Universität Berlin
2012 - 2016 - Faculty Member, IRI Graduate School “Single Molecule RNA Biology“, Humboldt Universität zu Berlin
2011 - 2015 - Faculty Member, Leibniz Graduate School “Molecular Biophysics“, Leibniz- Institut für Molekulare Pharmakologie, Berlin-Buch
2008 - 2009 - Professor (W2) of Macromolecular Crystallography, Georg-August- Universität Göttingen
2008 - 2009 - Faculty Member, International Max-Planck Research School “Physics of Biological and Complex Systems“, Max-Planck-Institut für Biophysikalische Chemie and Georg-August-Universität Göttingen
2007 - 2009 - Faculty Member, Graduate School “Biomolecules: Structure-Function- Dynamics”, Georg-August-Universität Göttingen
2006 - Call as a Professor (W3) of Biochemistry, Universität Bayreuth; declined
2003 - 2009 - Faculty Member, International Max-Planck Research School “Molecular Biology“, Max-Planck-Institut für Biophysikalische Chemie and Georg- August-Universität Göttingen
2002 - 2009 - Research Group Leader, Department of Cellular Biochemistry, Max-Planck- Institut für Biophysikalische Chemie, Göttingen (tenured in 2007)
2002 - 2008 - Lecturer (Privatdozent), Technische Universität München
1997 - 2002 - Postdoctoral fellow with Robert Huber, Max-Planck-Institut für Biochemie, Martinsried
1996 - Postdoctoral research fellow with Muttaiya Sundaralingam, The Ohio State University

Coordinating functions and editorial work

2011 - present - Member of the Executive Committee of the Collaborative Research Center 958 “Scaffolding of Membranes“
2009 - present - Founding Member “Joint Berlin MX Laboratory“
2018 - Chair, Symposium “Nucleic Acids and Interactions with Proteins”, 31st European Crystallographic Meeting, Oviedo, Spain
2017 - Chair, Symposium “Interactions Between Proteins and Nucleic Acids”, 24th IUCr Congress, Hyderabad, India
2014 - 2015 - Member of the Organizing Committee, 40. FEBS Congress “The Biochemical Basis of Life“, 2015, Berlin
2012 - 2016 - Co-Spokesperson of the Einstein Network “Single Molecule RNA Biology - Dynamics and Function of RNA from Transcription to Degradation“

Most important publications

  1. Krupp F, Said N, Huang YH, Loll B, Bürger J, Mielke T, Spahn CMT, Wahl MC (2019) Structural basis for the action of an all-purpose transcription anti-termination factor. Mol Cell 74:143-157

  2. Said N, Krupp F, Anedchenko E, Santos KF, Dybkov O, Huang YH, Lee TC, Loll B, Behrmann E, Bürger J, Mielke T, Loerke J, Urlaub H, Spahn CMT, Weber G, Wahl MC (2017) Structural basis for λN-dependent processive transcription antitermination, Nat Microbiol 2:17062

  3. Absmeier E, Wollenhaupt J, Mozaffari-Jovin S, Becke C, Lee CT, Marco Preussner M, Heyd F, Urlaub H, Lührmann R, Santos KF, Wahl MC (2015) The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes Dev 29:2576-2587

  4. Mozaffari Jovin S, Wandersleben T, Santos KF, Will CL, Lührmann R, Wahl MC (2013) Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science 341:80-84

  5. Burmann BM, Schweimer K, Luo X, Wahl MC, Stitt BL, Gottesman ME, Rösch P (2010) A NusE:NusG complex links transcription and translation. Science 328:501-504

  6. Wahl MC, Will CL, Lührmann R (2009) The spliceosome: Design principles of a highly dynamic molecular RNP machine. Cell 136:701-718

  7. Stein A, Weber G, Wahl MC, Jahn R (2009) Helical extension of the neuronal SNARE complex into the membrane. Nature 460:525-528

  8. Mukherjee K, Sharma M, Urlaub H, Bourenkov GP, Jahn R, Südhof TC, Wahl MC (2008) CASK functions as a Mg2+-independent neurexin kinase. Cell 133:328-339

  9. Liu S, Li P, Dybkov O, Nottrott S, Hartmuth K, Lührmann R, Carlomagno T, Wahl MC (2007) Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. Science 316:115-120

  10. Diaconu M, Kothe U, Schlünzen F, Fischer N, Harms J, Tonevitski AG, Stark H, Rodnina MV, Wahl MC (2005) Structural basis for the function of the ribosomal L7/12-stalk in factor binding and activation of GTP hydrolysis. Cell 121:991-1004