Prof. Dr. Michael Boutros

Prof. Dr. Michael Boutros

Lehrstuhl Zell- und Molekularbiologie
Universität Heidelberg / Zell- und Molekularbiologie
DKFZ / Signalwege und funktionelle Genomik
Im Neuenheimer Feld 580
69120 Heidelberg
Phone: + 49 (0) 6221 421951
Boutros@uni-heidelberg.de


Research Area

Cell Biology, Developmental Genetics, Genome Biology


Position and Status

Professor for Cell and Molecular Biology (W3), Head of Division


Scholarships and awards

2019 - ERC Synergy Grant
2013 - Elected EMBO Member
2012 - ERC Advanced Grant
2007 - Johann-Georg Zimmermann Award for Cancer Research
2006 - GO-Bio Award of the German Ministry of Research (BMBF)
2005 - EMBO Young Investigator Award
2003 - 2008 - Member of the Die Junge Akademie at the Berlin-Brandenburgischen Academy of Sciences and the Academy Leopoldina
2001 - 2003 -  Emmy-Noether Postdoctoral Fellowship and Junior Group (DFG)
1997 - 1999 -  Boehringer Ingelheim PhD fellowship
1991 - 1999 - Fellow of the Studienstiftung des deutschen Volkes



University training and degree

10/1995 - 08/1996 - Diploma thesis with Winship Herr at Cold Spring Harbor Laboratory, New York, USA
10/1993 - 08/1996 - Study of Biochemistry at Witten/Herdecke University, Witten
10/1991 - 10/1993 - Study of Biology at RWTH Aachen, Aachen

 

Advanced academic qualifications

1999 - Ph.D. in Molecular Biology, EMBL and Heidelberg University, Mentor: Marek Mlodzik

 

Postgraduate professional career

09/2015 - 11/2016 - Scientific Director (interim), German Cancer Research Center (DKFZ), Heidelberg
10/2008 - present - Professor of Cell and Molecular Biology, Heidelberg University
10/2008 - present - Head of Division, German Cancer Research Center (DKFZ), Heidelberg
07/2003 - 09/2008 - Group leader, DKFZ, Heidelberg, supported by the Emmy Noether Program
08/1999 - 06/2003 - Postdoctoral research fellow with Norbert Perrimon at Harvard Medical School, Boston, USA

Coordinating functions and editorial work

2019 - present - Coordinating PI, ERC Synergy Grant DECODE
2017 - present - Vice-Speaker, SFB1324
2016 - 2020 - Elected Member of the DFG panel 201-02 “Genetics”
2014 - present - Editorial Board Member, Molecular Systems Biology
2014 - present - Coordinator of the Research Program “Functional and Structural Genomics”, DKFZ, Heidelberg
2012 - present - Member of the Board (Kuratorium), Vice-Chair of the Board (since 2016), Studienstiftung des deutsche Volkes
2012 - present - Member of the Executive Board and PI, Excellence Cluster CellNetworks, Heidelberg University
2008 - present - Member of the Executive Board and PI, Excellence Graduate School HBIGS, Heidelberg University
2011 - 2013 - Vice-Dean for Research, Medical Faculty Mannheim, Heidelberg University
2010 - 2014 - Elected Member of the Senate of Heidelberg University
2010 - 2013 - Coordinator of the ERASysBio+ project “ApoNET”
2008 - 2011 - Coordinator of the FP7 project "CancerPathways"

Most important publications

  1. Heigwer, F., Scheeder, C., Miersch, T., Schmitt, B, Blass, C., Vali Pour-Jamnani, M., Boutros, M. (2018) Time-resolved mapping of genetic interactions to model rewiring of signaling pathways. eLife 7: e40174

  2. Mattila, J., Kokki, K., Hietakangas, V., Boutros, M. (2018) Stem cell intrinsic hexosamine metabolism regulates intestinal adaptation to nutrient content. Developmental Cell 24: 3072-308

  3. Glaeser, K., Urban, M., Fenech, E., Voloshanenko, O., Kranz, D., Lari, F., Christianson, J.C., Boutros, M. (2018) ERAD-dependent control of the Wnt secretory factor Evi. EMBO Journal 37: e97311

  4. Billmann, M., Chaudhary, V., ElMaghraby, M., Fischer, B., Boutros, M. (2018) Widespread rewiring of genetic networks upon cancer signaling pathway activation. Cell Systems 6: 52-64

  5. Demir, K., Kirsch, N., Beretta, C.A., Erdmann, G., Ingelfinger, D., Moro, E., Argenton, F., Carl, M., Niehrs, C., Boutros, M. (2013) RAB8B is required for activity and caveolar endocytosis of LRP6. Cell Reports 4: 1224-1234

  6. Gross, J.C., Chaudhary, V., Bartscherer, K., Boutros, M. (2012) Active Wnt proteins are secreted on exosomes. Nature Cell Biology 14: 1036–1045

  7. Horn, T., Sandmann, T., Fischer, B., Axelsson, E., Huber, W., Boutros, M. (2011) Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Nature Methods 8: 341–346

  8. Buechling, T., Bartscherer, K., Ohkawara, B., Chaudhary, V., Spirohn, K., Niehrs, C., Boutros, M. (2010) Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Current Biology 20: 1263–1268

  9. Bartscherer, K., Pelte, N., Ingelfinger, D., Boutros, M. (2006) Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 125: 523–533

  10. Müller, P., Kuttenkeuler, D., Gesellchen, V., Zeidler, M.P., Boutros, M. (2005) Identification of JAK/STAT signalling components by genome-wide RNA interference. Nature 436: 871–875