Dr. Joachim Moser von Filseck

Moser

Biochemie-Zentrum der Universität Heidelberg, Germany

E-Mail: joachim.moser@bzh.uni-heidelberg.de

Phone: +49 (0) 6221 54 4371

 


Research Area

Molecular mechanisms of membrane remodeling


Position and Status

Emmy Noether Research Group Leader


Scholarships and awards

2021 DFG Emmy Noether Fellowship

2021 CNRS and Inserm ATIP-Avenir Programme to start an independent research group in Grenoble (declined)

2018 SystemsX.ch Transition Postdoc Fellowship

2016 – 2017 EMBO long-term Postdoctoral Fellowship

2015 Two PhD thesis awards, from the Graduate School of Life Sciences, University of Nice-Sophia Antipolis, and GERLI (lipids section of the French Society for Biochemistry and Molecular Biology SFBBM), respectively



University training and degree

2006 – 2009, B.Sc. Chemistry, Heidelberg University, Germany, Thesis supervisor Prof. Irmgard Sinning

2009 – 2011, M.Sc. Chemistry, Montpellier University, France, Thesis supervisor Prof. Christian Périgaud

 

Advanced academic qualifications

2014 - PhD Biochemistry, University of Nice-Sophia Antipolis, France, Thesis supervisor: Dr. Guillaume Drin, Dr. Bruno Antonny

 

Postgraduate professional career

2022 – present Emmy Noether Research Group Leader, Heidelberg University Biochemistry Center, Germany

2015 – 2021 Postdoctoral fellow with Prof. Aurélien Roux, Biochemistry Department, University of Geneva, Switzerland

2015 – present Reviewer for scientific journals (including Cell Reports, Current Biology, Journal of Cell Science, Molecular Biology of the Cell, Nature Cell Biology, Scientific Reports, Trends in Cell Biology)

  1. Pfitzner, A.-K., Mercier, V., Jiang, X., Moser von Filseck, J., Baum, B., Šarić, A. & Roux, A. An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission. Cell 182, 1140-1155.e1118 (2020). https://doi.org/10.1016/j.cell.2020.07.021
  2. Moser von Filseck, J., Barberi, L., Talledge, N., Johnson, I. E., Frost, A., Lenz, M. & Roux, A. Anisotropic ESCRT-III architecture governs helical membrane tube formation. Nature Communications 11, 1516 (2020). https://doi.org/10.1038/s41467-020-15327-4
  3. Wang, L., Sadler, S., Cao, T., Xie, X., Moser von Filseck, J. & Bakker, E. Simplified Fabrication for Ion-Selective Optical Emulsion Sensor with Hydrophobic Solvatochromic Dye Transducer: A Cautionary Tale. Analytical Chemistry 91, 8973-8978 (2019). https://doi.org/10.1021/acs.analchem.9b01145 4
  4. Mierzwa, B. E., Chiaruttini, N., Redondo-Morata, L., Moser von Filseck, J., König, J., Larios, J., Poser, I., Müller-Reichert, T., Scheuring, S., Roux, A. & Gerlich, D. W. Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis. Nature Cell Biology 19, 787-798 (2017). https://doi.org/10.1038/ncb3559
  5. Moser von Filseck, J., Čopič, A., Delfosse, V., Vanni, S., Jackson, C. L., Bourguet, W. & Drin, G. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4- phosphate. Science 349, 432-436 (2015). DOI:10.1126/science.aab1346
  6. Moser von Filseck, J., Vanni, S., Mesmin, B., Antonny, B. & Drin, G. A phosphatidylinositol-4- phosphate powered exchange mechanism to create a lipid gradient between membranes. Nature Communications 6, 6671 (2015). https://doi.org/10.1038/ncomms7671
  7. Mesmin, B., Bigay, J., Moser von Filseck, J., Lacas-Gervais, S., Drin, G. & Antonny, B. A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP. Cell 155, 830-843 (2013). DOI: 10.1016/j.cell.2013.09.056