Dr. Steeve Boulant

SteeveBoulant

Medizinische Fakultät Heidelberg der Universität Heidelberg
Zentrum für Infektiologie, Virologie
Im Neuenheimer Feld 344
69120 Heidelberg
E-Mail: S.Boulant@dkfz.de
Phone: +49 (6221) 56-7865 


Research Area

Virology, Immunity, Molecular Cell Biology, Intracellular Trafficking


Position and Status

Junior Group Leader


Scholarships and awards

2019 Loeffler Frosch Prize attributed by the German society of virology (GfV)
2011 Postdoctoral fellowship (2011-2012), GlaxoSmithKline, Boston MA, USA
2010 Pilot and Feasibility award program HDDC, Boston MA, USA
2009 Pilot and Feasibility award program HDDC, Boston MA, USA
2007 Poster award, FASEB Lipid Droplets conference, Vermont USA
2006 Postdoctoral fellowship Marie Curie IEF (2006-2008), Glasgow, UK
2006 Best Oral communication, UK Meeting on the Biology and Pathology of HCV
2005 Postdoctoral fellowship (2005-2006), MRC, Glasgow, UK
2005 Travel award, 11th International Meeting on HCV and Related Viruses
2004 Bridging grant, FRM (2004-2005), Lyon, France
2001 EURODOC fellowship, Lyon-Glasgow exchange grant



University training and degree

2000 - 2001 - Master degree in Molecular Biology and Biochemistry, University of Lyon, France
1998 - 2000 - Bachelor degree in Molecular Biology and Biochemistry, University of Lyon, France

 

Advanced academic qualification

2003 - Ph.D. in Molecular Biology and Biochemistry at the Institute of biology and chemistry of proteins, Lyon, France. Mentors: Dr. Lavergne and Dr. Penin

 

Postgraduate professional career

2019 - present - Heisenberg Fellow from the DFG
2012 - present - Junior Group Leader CHS Foundation, University Hospital Heidelberg
2008 - 2012 - Postdoctoral associate, Harvard Medical School Boston MA, USA
2006 - 2008 - Marie Curie Postdoctoral fellow, MRC Virology Unit Glasgow, UK
2005 - 2006 - Postdoctoral associate, MRC Virology Unit Glasgow, UK

Coordinating Functions and Editorial Work

2013 - Chair of the study section “Cell Biology of Viral Infections” of the Society of Virology (GfV)
2010 - Co-organizer of live-cell imaging workshop, Harvard Medical School, USA

Most important publications

*co-senior author

  1. Stanifer,M; Mukenhirn, M; Muenchau, S; Pervolaraki,K; Kanaya,T; Albrecht,D; Haucke, V; Odendall,C; Kagan, JC; Bartfeld,S; Ohno, H; and Boulant, S. (2019) Cellular polarity asymmetrically functionalizes pathogen recognition receptor-mediated intrinsic immune response in human intestinal epithelium cells. Nature Microbiology. https://doi.org/10.1038/s41564-019-0594-3

  2. Muenchau S, Deutsch R, de Castro IJ, Hielscher T, Heber N, Niesler B, Lusic M, Stanifer ML, Boulant S. (2019) Hypoxic environment promotes barrier formation in human intestinal epithelial cells through regulation of miRNA-320a expression. Mol Cell Biol. May 6

  3. Pervolaraki K, Rastgou Talemi S, Albrecht D, Bormann F, Bamford C, Mendoza JL, Garcia KC, McLauchlan J, Höfer T, Stanifer ML, Boulant S. (2018) Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance. PLoS Pathog. Nov 28;14(11):e1007420.

  4. Bucher D, Frey F, Sochacki KA, Kummer S, Bergeest JP, Godinez WJ, Kräusslich HG, Rohr K, Taraska JW, Schwarz US, Boulant S. (2018) Clathrin-adaptor ratio and membrane tension regulate the flat-to- curved transition of the clathrin coat during endocytosis. Nat Commun. Mar 16;9(1):1109.

  5. Odendall C, Dixit E, Stavru F, Bierne H, Franz KM, Durbin AF, Boulant S, Gehrke L, Cossart P, Kagan JC. (2014) Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nat Immunol. 15(8):717-26.

  6. Boulant S*, Stanifer M, Kural C, Cureton DK, Massol R, Nibert ML, Kirchhausen T (2013) Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 24(8):1196-207.

  7. Ema Cocucci, Francois Aguet, Steeve Boulant and Tom Kirchhausen (2012) The first five seconds in the life of a clathrin coated pit. Cell 150(3):495-507

  8. Kural C, Tacheva-Grigorova SK, Boulant S, Cocucci E, Baust T, Duarte D, Kirchhausen T. (2012) Dynamics of intracellular clathrin/AP1- and clathrin/AP3-containing carriers. Cell Rep. 2(5):1111-9

  9. Steeve Boulant, Comert Kural, Jean-Christophe Zeeh and Tom Kirchhausen (2011) Actin dynamics counteract membrane tension during clathrin-mediated endocytosis. Nat Cell Biol. 13(9):1124-31

  10. Evelyn Dixit, Steeve Boulant, Yijing Zhang, Amy S. Lee, Bennett O.V. Shum, Nir Hacohen, Zhijian J. Chen, Sean P. Whelan, Marc Fransen, Max L. Nibert, Giulio Superti-Furga, Jonathan C. Kagan. (2011) Peroxisomes and mitochondria cooperate to induce antiviral innate immunity. Cell 141(4):668-81